Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.44 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924999 | 0.81 | PARP1 (0.48) | PARP1CHEK1PARP2PARP3ALDH1A1 | |
| SCHEMBL29817837 | 0.79 | PARP1 (0.59) | PARP1CHEK1PARP2PARP3LMNA | |
| SCHEMBL28847349 | 0.75 | KDM4E (0.49) | PARP1CHEK1PARP2PARP3GAA | |
| SCHEMBL16655571 | 0.75 | ALDH1A1 (0.50) | PARP1PARP2PARP3LMNAALDH1A1 | |
| SCHEMBL5482646 | 0.75 | PPARG (0.45) | PARP1GAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL16121663 | 0.75 | CHKA (0.62) | PARP1CHEK1PARP2PARP3 | |
| SCHEMBL28282551 | 0.72 | BCAT2 (0.50) | PARP1GAAALDH1A1GRM2KDM4E | |
| SCHEMBL4878350 | 0.72 | HDAC3 (0.55) | PARP1PARP2PARP3LMNAALDH1A1 | |
| SCHEMBL6004326 | 0.70 | BCAT2 (0.71) | PARP1CHEK1LMNAGAATSHR | |
| SCHEMBL31419622 | 0.68 | BCAT2 (0.49) | PARP1GAAALDH1A1GRM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013035102-A1 | PROCESSES FOR THE PREPARATION OF IMATINIB BASE AND INTERMEDIATES THEREOF | NATCO PHARMA LIMITED (IN) | 2013-03-14 | — | — | WO | disclosed |
| EP-1833815-B1 | A PROCESS FOR PREPARATION OF IMATINIB BASE | INST FARMACEUTYCZNY (PL) | 2010-09-15 | — | — | EP | disclosed |
| US-7674901-B2 | Process for preparation of imatinib base | INSTYTUT FARMACEUTYCZNY (PL) | 2010-03-09 | — | — | US | disclosed |
| US-20080194819-A1 | Process For Preparation of Imatinib Base | INSTYTUT FARMACEUTYCZNY (PL) | 2008-08-14 | — | — | US | disclosed |
| EP-1833815-A2 | A PROCESS FOR PREPARATION OF IMATINIB BASE | INSTYTUT FARMACEUTYCZNY (PL) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071130-A2 | A PROCESS FOR PREPARATION OF IMATINIB BASE | INSTYTUT FARMACEUTYCZNY (PL) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194819-A1 | Process For Preparation of Imatinib Base | ABL1, ABL2, JAK2 | PARP1 895/4885CHEK1 2204/4885PARP2 1196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.