Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5476512 | 0.88 | BCAT2 (0.59) | PPARGBCAT2PARP1LTB4R2SYK | |
| SCHEMBL16463457 | 0.82 | PARP1 (0.40) | PPARGBCAT2PARP1DPP4SYK | |
| SCHEMBL20547008 | 0.82 | MKNK1 (0.46) | PPARGBCAT2LTB4R2ALDH1A1MAPT | |
| SCHEMBL370726 | 0.81 | MYC (0.45) | PPARGBCAT2PARP1DPP4KDM4E | |
| SCHEMBL2964481 | 0.81 | PARP1 (0.45) | BCAT2PARP1KDM4EALDH1A1GAA | |
| SCHEMBL4235369 | 0.78 | CXCR5 (0.49) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL6004326 | 0.77 | BCAT2 (0.71) | PPARGBCAT2PARP1LTB4R2KDM4E | |
| SCHEMBL5478290 | 0.77 | PARP1 (0.45) | PPARGBCAT2PARP1KDM4EALDH1A1 | |
| SCHEMBL28282551 | 0.76 | BCAT2 (0.50) | BCAT2PARP1KDM4EUSP2ALDH1A1 | |
| SCHEMBL28149292 | 0.76 | BCAT2 (0.50) | PPARGBCAT2LTB4R2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |