Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977932 | 0.85 | ALDH1A1 (0.60) | PPARAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL979564 | 0.83 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTNPC1HPGD | |
| SCHEMBL979627 | 0.77 | ALDH1A1 (0.63) | PPARAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL979194 | 0.74 | KMT2A (0.62) | ALDH1A1SMN1; SMN2MAPTNPC1HPGD | |
| SCHEMBL4108679 | 0.73 | ALDH1A1 (0.49) | PPARAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL978615 | 0.72 | KMT2A (0.57) | PPARAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL3735358 | 0.70 | PTGES (0.44) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL979379 | 0.69 | GAA (0.61) | PPARAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL2930244 | 0.68 | CHEK1 (0.41) | PPARAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4740518 | 0.66 | ALDH1A1 (0.81) | PPARAALDH1A1SMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217566-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066 | AstraZeneca AB (SE) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009064251-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066 | ASTRAZENECA AB (SE) | 2009-05-22 | — | — | WO | disclosed |