Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | USP2 | O75604 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926144 | 0.88 | ALDH1A1 (0.37) | ALDH1A1PARP1LMNAGAAPRMT5 | |
| SCHEMBL2919447 | 0.75 | LMNA (0.47) | ALDH1A1TSHRLMNAMAPTMEN1 | |
| SCHEMBL6191366 | 0.70 | P2RX7 (0.40) | TSHRLMNAPRMT5MAPTMEN1 | |
| SCHEMBL2916241 | 0.64 | MAPT (0.52) | ALDH1A1TSHRLMNAMAPTMEN1 | |
| SCHEMBL2923534 | 0.61 | MAPK1 (0.45) | ALDH1A1TSHRLMNAGAAMAPT | |
| SCHEMBL2917012 | 0.58 | AURKA (0.65) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL2947129 | 0.58 | MEN1 (0.49) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL7240204 | 0.57 | ALDH1A1 (0.42) | ALDH1A1TSHRLMNAGAANPC1 | |
| SCHEMBL2917150 | 0.56 | ALDH1A1 (0.44) | ALDH1A1GAANPC1MEN1KMT2A | |
| SCHEMBL6193906 | 0.56 | P2RX7 (0.40) | ALDH1A1TSHRLMNAGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |