Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | RORB | Q92753 | 3/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924875 | 0.89 | HCRTR2 (0.37) | HCRTR1HCRTR2KDM4ECHRM3 | |
| SCHEMBL2930629 | 0.89 | RORB (0.46) | HCRTR1HCRTR2S1PR5RORBRORC | |
| SCHEMBL2929505 | 0.88 | HCRTR2 (0.43) | HCRTR1HCRTR2CHRM3 | |
| SCHEMBL2925064 | 0.88 | HCRTR2 (0.43) | HCRTR1HCRTR2CHRM3 | |
| SCHEMBL2929133 | 0.86 | HCRTR1 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL2926155 | 0.86 | HDAC7 (0.43) | HCRTR1HCRTR2CHRM3 | |
| SCHEMBL2933413 | 0.86 | RORB (0.38) | HCRTR1HCRTR2S1PR5RORBRORC | |
| SCHEMBL2930272 | 0.86 | CHRM1 (0.46) | HCRTR1HCRTR2RORBRORCCHRM3 | |
| SCHEMBL2925368 | 0.85 | HCRTR1 (0.41) | HCRTR1HCRTR2S1PR5CHRNA7TRPV1 | |
| SCHEMBL2931139 | 0.84 | HCRTR1 (0.39) | HCRTR1HCRTR2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | claimed |
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |