Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 3/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29894060 | 1.00 | CHRM1 (0.53) | CHRM1PARP1PARP2KDM4EAPEX1 | |
| SCHEMBL1917771 | 0.87 | RIPK1 (0.44) | KDM4EL3MBTL1MAPTCYP1A2GAA | |
| SCHEMBL9197306 | 0.85 | RIPK1 (0.48) | PARP1KDM4EL3MBTL1MAPTCYP1A2 | |
| SCHEMBL7721019 | 0.84 | DDAH1 (0.44) | KDM4EL3MBTL1MAPTGAAKMT2A | |
| SCHEMBL3079241 | 0.84 | MAPT (0.43) | KDM4EMAPTPOLBGAAKMT2A | |
| SCHEMBL7002080 | 0.83 | KDM4E (0.48) | KDM4EL3MBTL1MAPTGAAKMT2A | |
| SCHEMBL1552358 | 0.82 | RNASEH1 (0.54) | KDM4EL3MBTL1MAPTCYP1A2CYP2C9 | |
| SCHEMBL937977 | 0.82 | PKM (0.48) | KDM4EL3MBTL1MAPTPOLBGAA | |
| SCHEMBL20594099 | 0.80 | MAPT (0.46) | KDM4EL3MBTL1MAPTCYP1A2GAA | |
| SCHEMBL10691303 | 0.78 | POLB (0.46) | POLBGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-115023419-A | Cereblon-bound piperidine-2, 6-diones and methods of use thereof | 凯普托尔治疗学股份有限公司 | 2022-09-06 | — | — | CN | disclosed |