Isothiocyanate

Isothiocyanate

SCHEMBL29287693

N=C=S.O=[N+]([O-])c1cccc(-c2ccccc2)c1F

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.57
TDP1 Q9NUW8 3/20 0.57
S100A4 P26447 2/20 0.41
PTPRC P08575 1/20 0.41
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
MAOA P21397 1/20 0.38
CRHBP P24387 1/20 0.38
CRHR2 Q13324 1/20 0.38
HPGD P15428 1/20 0.37
GPR35 Q9HC97 1/20 0.37
TSHR P16473 1/20 0.37
MAPT P10636 1/20 0.36
RECQL P46063 1/20 0.36
MCL1 Q07820 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MYC P01106 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1999472 0.91 ALDH1A1 (0.69) ALDH1A1TDP1S100A4PTPRCKMT2A
SCHEMBL29565552 0.78 ALDH1A1 (0.56) ALDH1A1TDP1S100A4PTPRCKMT2A
SCHEMBL26164145 0.78 ALDH1A1 (0.56) ALDH1A1TDP1S100A4PTPRCKMT2A
SCHEMBL9760964 0.77 ALDH1A1 (0.81) ALDH1A1TDP1S100A4PTPRCKMT2A
SCHEMBL11617176 0.77 TDP1 (0.57) ALDH1A1TDP1S100A4PTPRCKMT2A
Isothiocyanate SCHEMBL29287690 0.76 ALDH1A1 (0.49) ALDH1A1TDP1S100A4PTPRCKMT2A
SCHEMBL14956663 0.75 VCAM1 (0.47) ALDH1A1TDP1S100A4PTPRCKMT2A
SCHEMBL29180134 0.75 ALDH1A1 (0.92) ALDH1A1TDP1S100A4PTPRCKMT2A
SCHEMBL30196067 0.74 ALDH1A1 (1.00) ALDH1A1TDP1S100A4PTPRCKMT2A
SCHEMBL44392 0.74 ALDH1A1 (1.00) ALDH1A1TDP1S100A4PTPRCKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103965134-B It is a kind of to contain N, S heterocyclic compound and its preparation method and purposes with eelworm-killing activity 华东理工大学 2019-02-05 CN disclosed