Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28786717 | 0.89 | ALDH1A1 (0.42) | NOTUMCACNA1HALDH1A1KDM4EMAPT | |
| SCHEMBL4787452 | 0.72 | CHEK1 (0.54) | ALDH1A1KDM4EMAPTNPC1GAA | |
| SCHEMBL308438 | 0.71 | CA12 (0.45) | — | |
| SCHEMBL22836610 | 0.71 | MAOB (0.45) | ALDH1A1KDM4EKMOMAPK1NPC1 | |
| SCHEMBL29615973 | 0.71 | MAOB (0.45) | ALDH1A1KDM4EKMOMAPK1NPC1 | |
| SCHEMBL29288245 | 0.71 | ALDH1A1 (0.40) | ALDH1A1KDM4ETFPI2NPC1GAA | |
| SCHEMBL31662536 | 0.70 | KMT2A (0.48) | NOTUMCACNA1HALDH1A1KDM4EMAPT | |
| SCHEMBL3438334 | 0.70 | HCAR3 (0.56) | ALDH1A1KDM4EMAPTKMONPC1 | |
| SCHEMBL18366383 | 0.70 | HTT (0.45) | NOTUMALDH1A1KDM4EMAPTKMO | |
| SCHEMBL5396657 | 0.70 | HCAR3 (0.52) | NOTUMKMONPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105078993-B | A kind of indazole compounds composition and its preparation method and application | 浙江大果生物医药科技有限公司 | 2019-02-22 | — | — | CN | claimed |