SCHEMBL2929447

SCHEMBL2929447

CC(OC(=O)O)c1ccccc1I

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.38
TSHR P16473 1/20 0.37
PDCD1 Q15116 1/20 0.36
CD274 Q9NZQ7 1/20 0.36
GAA P10253 3/20 0.34
KMT2A Q03164 3/20 0.34
LMNA P02545 1/20 0.34
MTNR1A P48039 3/20 0.33
MTNR1B P49286 3/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MEN1 O00255 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
LPAR1 Q92633 1/20 0.33
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
POLB P06746 1/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5579233 0.85 ALDH1A1 (0.39) HCAR2TSHRKMT2ALMNAMTNR1A
SCHEMBL26816137 0.80 ELANE (0.36) HCAR2TSHRGAALMNAMTNR1A
SCHEMBL28393933 0.79 ESR1 (0.45) HCAR2TSHRPDCD1CD274POLB
SCHEMBL535719 0.79 CES2 (0.43) HCAR2KMT2ALMNASMN1; SMN2MEN1
Iodide SCHEMBL5873850 0.78 ELANE (0.36) HCAR2TSHRLMNASMN1; SMN2NPSR1
Iodide SCHEMBL5873855 0.78 ELANE (0.36) HCAR2TSHRLMNASMN1; SMN2NPSR1
SCHEMBL8906867 0.78 LPAR1 (0.49) LMNALPAR1
SCHEMBL1790920 0.75 TDP1 (0.40) HCAR2TSHRGAATDP1NPSR1
SCHEMBL5932136 0.75 ALDH1A1 (0.45) GAAKMT2ALMNAMEN1HTT
SCHEMBL647331 0.75 PTGS2 (0.47) TSHRKMT2ALMNASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2231623-A1 5-PHENYL-LH-BENZ0 [E] [1, 4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS Universita' Degli Studi di Firenze (IT) 2010-09-29 EP disclosed
WO-2009081349-A1 5-PHENYL-LH-BENZ0 [E] [1, 4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS UNIVERSITA' DEGLI STUDI DI FIRENZE (IT) 2009-07-02 WO disclosed