Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 2/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931482 | 0.92 | MEN1 (0.39) | MEN1KMT2AGPR6LPAR2HCAR1 | |
| SCHEMBL1760928 | 0.89 | FAAH (0.43) | MEN1KMT2APHGDH | |
| SCHEMBL3047619 | 0.87 | RIPK1 (0.37) | CXCR3SCDRIPK1RIPK3ADORA2A | |
| SCHEMBL2932276 | 0.87 | CYP2D6 (0.41) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2927982 | 0.87 | ADORA2B (0.47) | MEN1KMT2APHGDHADORA2AADORA2B | |
| SCHEMBL2930809 | 0.86 | LMNA (0.40) | MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL2932134 | 0.86 | PPARD (0.42) | GPR6 | |
| SCHEMBL2931938 | 0.85 | PIK3CD (0.37) | CXCR3SCDRIPK1RIPK3ADORA2A | |
| SCHEMBL2931313 | 0.85 | LRRK2 (0.38) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2924971 | 0.85 | CCR3 (0.40) | LPAR2HCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |