Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761050 | 0.90 | HPGDS (0.40) | KCNH2SFRP1MAPK7TRPV1LRRK2 | |
| SCHEMBL2931313 | 0.86 | LRRK2 (0.38) | KCNH2PIK3CDMAPK7LRRK2ADORA2A | |
| SCHEMBL2932134 | 0.85 | PPARD (0.42) | KCNH2PIK3CDPIK3R1PIK3CG | |
| SCHEMBL2927299 | 0.81 | PIK3CG (0.36) | PIK3CDPIK3R1ADORA2AADORA2BADORA1 | |
| SCHEMBL2931856 | 0.80 | ALDH1A1 (0.44) | ADORA2AADORA1 | |
| SCHEMBL2929996 | 0.77 | PKLR (0.38) | KCNH2TRPV1ADORA2AADORA2BADORA1 | |
| SCHEMBL1761042 | 0.76 | PPARD (0.43) | — | |
| SCHEMBL3041508 | 0.76 | PHGDH (0.47) | ADORA2A | |
| SCHEMBL2932276 | 0.76 | CYP2D6 (0.41) | TRPV1ADORA2AADORA2BADORA1 | |
| SCHEMBL1761048 | 0.75 | HPGDS (0.44) | KCNH2PIK3CDMAPK7LRRK2PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |