Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760940 | 0.90 | PIK3CD (0.39) | PIK3CGPIK3CDPIK3R1PIK3CAADORA2A | |
| SCHEMBL2932134 | 0.87 | PPARD (0.42) | PIK3CGPIK3CDPIK3R1 | |
| SCHEMBL3047619 | 0.87 | RIPK1 (0.37) | PIK3CDPIK3CAADORA2AADORA2BADORA1 | |
| SCHEMBL2931938 | 0.83 | PIK3CD (0.37) | PIK3CGPIK3CDPIK3CAADORA2AADORA2B | |
| SCHEMBL2929672 | 0.81 | KCNH2 (0.36) | PIK3CGPIK3CDPIK3R1ADORA2AADORA2B | |
| SCHEMBL2930816 | 0.79 | STAT3 (0.40) | — | |
| SCHEMBL2931791 | 0.79 | RPS6KB1 (0.37) | PIK3CDADORA2AADORA2BADORA1 | |
| SCHEMBL1761042 | 0.77 | PPARD (0.43) | — | |
| SCHEMBL1761043 | 0.77 | PIK3CD (0.40) | PIK3CGPIK3CDPIK3R1PIK3CAADORA2A | |
| SCHEMBL2931691 | 0.76 | TAS1R3 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |