Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.38 |
| ▸ | MPL | P40238 | 4/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761048 | 0.90 | HPGDS (0.44) | LRRK2MPLPDE2AP2RX7HPGDS | |
| SCHEMBL2931691 | 0.86 | TAS1R3 (0.45) | LRRK2 | |
| SCHEMBL2929672 | 0.86 | KCNH2 (0.36) | LRRK2PIK3CDPIK3CGKCNH2MAPK7 | |
| SCHEMBL2931742 | 0.85 | MEN1 (0.38) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2931856 | 0.84 | ALDH1A1 (0.44) | HPGDSADORA2AADORA1 | |
| SCHEMBL2932725 | 0.84 | TAS1R3 (0.42) | LRRK2PIK3CDPIK3CA | |
| SCHEMBL2931638 | 0.84 | TAS1R3 (0.42) | LRRK2PIK3CDPIK3CA | |
| SCHEMBL3047619 | 0.82 | RIPK1 (0.37) | P2RX7PIK3CDPIK3CAKCNH2ADORA2A | |
| SCHEMBL2931938 | 0.80 | PIK3CD (0.37) | P2RX7PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1760925 | 0.79 | TAS1R3 (0.47) | LRRK2PIK3CDPIK3CAADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |