Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 9/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493432 | 0.86 | CYP1A2 (0.37) | CYP1A2GRM8GRM7HTTCRHR1 | |
| SCHEMBL2495462 | 0.81 | KDM4E (0.38) | CYP1A2GRM8GRM7HTTCRHR1 | |
| SCHEMBL2498882 | 0.80 | POLB (0.39) | CYP1A2GRM8GRM7HTTCRHR1 | |
| SCHEMBL2929183 | 0.78 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL2933140 | 0.77 | CRHR1 (0.38) | CYP1A2GRM8GRM7HTTCRHR1 | |
| SCHEMBL2495432 | 0.76 | POLB (0.40) | CYP1A2GRM8GRM7HTTCRHR1 | |
| SCHEMBL2931328 | 0.76 | PIK3CG (0.38) | CYP1A2GRM8GRM7KDM4EPOLB | |
| SCHEMBL2932900 | 0.73 | CRHR1 (0.47) | CRHR1KDM4EPOLBLMNAALDH1A1 | |
| SCHEMBL2933954 | 0.72 | HPGD (0.34) | CYP1A2GRM8GRM7HTTCRHR1 | |
| SCHEMBL2933952 | 0.72 | HPGD (0.34) | CYP1A2GRM8GRM7HTTCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |