Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492930 | 0.84 | PIK3CG (0.38) | PIK3CGPIK3CAPIK3CDPIK3CBRIPK1 | |
| SCHEMBL2498882 | 0.83 | POLB (0.39) | KDM4EMAPTMEN1KMT2APOLB | |
| SCHEMBL2498943 | 0.83 | BRD4 (0.34) | ALDH1A1MEN1KMT2AGRM8CYP1A2 | |
| SCHEMBL2495462 | 0.82 | KDM4E (0.38) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL544898 | 0.81 | MAPT (0.42) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2933140 | 0.80 | CRHR1 (0.38) | KDM4EMAPTPOLBGRM8CYP1A2 | |
| SCHEMBL2495432 | 0.79 | POLB (0.40) | KDM4EMAPTMEN1KMT2APOLB | |
| SCHEMBL2493432 | 0.78 | CYP1A2 (0.37) | KDM4EMAPTMEN1KMT2APOLB | |
| SCHEMBL2932900 | 0.76 | CRHR1 (0.47) | PIK3CGKDM4EPIK3CAALDH1A1MEN1 | |
| SCHEMBL2929947 | 0.76 | CYP1A2 (0.34) | KDM4EMAPTALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |