Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928081 | 0.91 | OGA (0.37) | ADORA3ADORA2AADORA1MAPK1KIT | |
| SCHEMBL1760947 | 0.89 | PDGFRB (0.39) | MAPTADORA3ADORA2AADORA1MAPK1 | |
| SCHEMBL3049811 | 0.83 | MEN1 (0.42) | LMNAMAPTADORA2AMAPK1 | |
| SCHEMBL3039094 | 0.83 | TACR1 (0.36) | ADORA2AADORA1MC4R | |
| SCHEMBL2931856 | 0.82 | ALDH1A1 (0.44) | MAPTADORA3ADORA2AADORA1POLB | |
| SCHEMBL12647200 | 0.82 | PDGFRB (0.38) | MAPTADORA3ADORA2AADORA1MAPK1 | |
| SCHEMBL2932086 | 0.82 | ADORA3 (0.36) | LMNAMAPTADORA3ADORA2AADORA1 | |
| SCHEMBL2930009 | 0.80 | KMT2A (0.37) | MAPTADORA3ADORA2AADORA1 | |
| SCHEMBL2929673 | 0.79 | SCN9A (0.42) | ADORA3ADORA2AADORA1 | |
| SCHEMBL1760946 | 0.79 | PDGFRB (0.40) | KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |