Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760900 | 0.89 | EPHX2 (0.46) | SCN9AEPHX2ERBB2EGFRTRPA1 | |
| SCHEMBL2930009 | 0.83 | KMT2A (0.37) | SCN9AMEN1KMT2AADORA3ADORA2A | |
| SCHEMBL2931856 | 0.82 | ALDH1A1 (0.44) | MEN1KMT2AADORA3ADORA2AADORA1 | |
| SCHEMBL2932086 | 0.81 | ADORA3 (0.36) | MEN1KMT2AADORA3ADORA2AADORA1 | |
| SCHEMBL3049811 | 0.81 | MEN1 (0.42) | MEN1KMT2AADORA2A | |
| SCHEMBL2928081 | 0.81 | OGA (0.37) | ADORA3ADORA2AADORA1 | |
| SCHEMBL2930302 | 0.79 | USP2 (0.35) | ADORA3ADORA2AADORA1 | |
| SCHEMBL2931125 | 0.79 | EIF4E (0.41) | ADORA3ADORA2AADORA1HTR2C | |
| SCHEMBL2930544 | 0.79 | GHSR (0.36) | ADORA3ADORA2AADORA1 | |
| SCHEMBL2930985 | 0.79 | ALDH1A1 (0.47) | MEN1KMT2AADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |