Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PKLR | P30613 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930985 | 0.91 | ALDH1A1 (0.47) | KMT2AADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL1761066 | 0.88 | ADORA2A (0.47) | KMT2AADORA2AADORA1EP300CREBBP | |
| SCHEMBL2932713 | 0.88 | ADORA2A (0.49) | KMT2AADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL2929673 | 0.83 | SCN9A (0.42) | KMT2AADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL2931856 | 0.83 | ALDH1A1 (0.44) | KMT2AADORA2AADORA1ALDH1A1ADORA3 | |
| SCHEMBL2932086 | 0.82 | ADORA3 (0.36) | KMT2AADORA2AADORA1ALDH1A1ADORA3 | |
| SCHEMBL3049811 | 0.82 | MEN1 (0.42) | KMT2AADORA2AALDH1A1MEN1MAPT | |
| SCHEMBL2928081 | 0.81 | OGA (0.37) | ADORA2AADORA1ADORA3 | |
| SCHEMBL2929996 | 0.81 | PKLR (0.38) | ADORA2AADORA1ADORA2BPKLRADORA3 | |
| SCHEMBL2930302 | 0.80 | USP2 (0.35) | ADORA2AADORA1ADORA3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |