Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931856 | 0.84 | ALDH1A1 (0.44) | ADORA3ADORA2AADORA1MAPTKMT2A | |
| SCHEMBL3049811 | 0.84 | MEN1 (0.42) | ADORA2AMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL2928081 | 0.83 | OGA (0.37) | ADORA3ADORA2AADORA1 | |
| SCHEMBL2930009 | 0.82 | KMT2A (0.37) | ADORA3ADORA2AADORA1MAPTKMT2A | |
| SCHEMBL2930302 | 0.82 | USP2 (0.35) | ADORA3ADORA2AADORA1MAPTLMNA | |
| SCHEMBL2929673 | 0.81 | SCN9A (0.42) | ADORA3ADORA2AADORA1KMT2AMEN1 | |
| SCHEMBL2930809 | 0.79 | LMNA (0.40) | ADORA3ADORA2AADORA1MAPTKMT2A | |
| SCHEMBL2932222 | 0.78 | KDM4E (0.38) | ADORA3ADORA2AADORA1KMT2AMEN1 | |
| SCHEMBL2930508 | 0.78 | GPR6 (0.34) | ADORA3ADORA2AADORA1 | |
| SCHEMBL2929411 | 0.78 | ADORA2A (0.41) | ADORA3ADORA2AADORA1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |