Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931328 | 0.81 | PIK3CG (0.38) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL545543 | 0.81 | HPGD (0.40) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL15104244 | 0.80 | ALDH1A1 (0.39) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL544939 | 0.79 | CRHR1 (0.40) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL545948 | 0.79 | CRHR1 (0.40) | POLBHPGDCRHR1 | |
| SCHEMBL2931270 | 0.76 | HPGD (0.39) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2497805 | 0.75 | HPGD (0.38) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL12409295 | 0.75 | CRHR1 (0.40) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL544990 | 0.75 | HPGD (0.40) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL545592 | 0.75 | HPGD (0.38) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110580-B2 | Thiophene pyrazolopyrimidine compounds | ELI LILLY AND COMPANY (US) | 2012-02-07 | — | — | US | disclosed |
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CHEN ZHAOGEN | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022560-A1 | THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS | CRH, CRHR1, CRHR2 | MAPT 1164/4885ALDH1A1 2135/4885KDM4E 4111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.