Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.61 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923321 | 0.89 | CYP2A13 (0.61) | HIF1AEPAS1KCNH2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2926471 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1L3MBTL1LMNAHRH3 | |
| SCHEMBL4115394 | 0.79 | SIGMAR1 (0.72) | SMN1; SMN2ALDH1A1L3MBTL1MEN1HPGD | |
| SCHEMBL2930005 | 0.78 | SIGMAR1 (0.49) | SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL632349 | 0.77 | EGFR (0.59) | ALDH1A1MEN1HPGDKMT2ALMNA | |
| SCHEMBL1964857 | 0.77 | HDAC4 (0.54) | SMN1; SMN2ALDH1A1L3MBTL1HPGDNPC1 | |
| Ammonia Solution, Strong SCHEMBL2931430 | 0.76 | SIGMAR1 (0.58) | SMN1; SMN2ALDH1A1L3MBTL1MEN1PRKD3 | |
| SCHEMBL631634 | 0.74 | LMNA (0.59) | SMN1; SMN2ALDH1A1MEN1HPGDKMT2A | |
| 4-(4-Chlorobenzyl)Morpholine SCHEMBL4103722 | 0.74 | HRH3 (0.74) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL15467001 | 0.73 | HRH3 (0.87) | HIF1AEPAS1SMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121616-B1 | NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS | CAMPIANI GIUSEPPE (IT) | 2010-09-15 | — | — | EP | disclosed |
| US-20100093726-A1 | NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS | GIUSEPPE CAMPIANI (IT) | 2010-04-15 | — | — | US | disclosed |
| EP-2121616-A1 | NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS | Campiani, Giuseppe (IT) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008101891-A1 | NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS | CAMPIANI GIUSEPPE (IT) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093726-A1 | NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS | QTRT1, QTRT2, IL4I1 | HIF1A 3412/4885EPAS1 2058/4885KCNH2 2280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.