Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | PRKCA | P17252 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7102271 | 0.98 | LMNA (0.58) | LMNAMAOBPLA2G1BHPGDATG4B | |
| SCHEMBL632217 | 0.90 | CHRM2 (0.55) | LMNAMAOBPLA2G1BHPGDATG4B | |
| SCHEMBL11513070 | 0.90 | FFAR1 (0.57) | LMNAMAOBPLA2G1BHPGDATG4B | |
| SCHEMBL632349 | 0.89 | EGFR (0.59) | LMNAMAOBPLA2G1BHPGDATG4B | |
| SCHEMBL1196472 | 0.89 | MAOB (0.56) | LMNAMAOBPLA2G1BHPGDATG4B | |
| SCHEMBL6700054 | 0.86 | CHRM2 (0.55) | MAOBKDM4EMAPTGAAMEN1 | |
| SCHEMBL6690772 | 0.86 | HTT (0.57) | MEN1KMT2AMETAP2 | |
| SCHEMBL11510373 | 0.85 | GAA (0.51) | LMNAMAOBPLA2G1BHPGDATG4B | |
| SCHEMBL12846667 | 0.84 | FFAR1 (0.62) | MAPTMEN1KMT2A | |
| SCHEMBL8546536 | 0.84 | HPGD (0.58) | LMNAMAOBPLA2G1BHPGDATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110294714-A | Imidazoles methylamine like derivative and its synthetic method with indoles amine -2,3- dioxygenase (IDO) inhibitor activity | 西华大学 | 2019-10-01 | — | — | CN | disclosed |
| CN-110294713-A | A kind of preparation method of imidazoles methylamine like derivative | 西华大学 | 2019-10-01 | — | — | CN | disclosed |
| CN-107793367-A | A kind of method for synthesizing people's Microsomal prostaglandin synthetase 1 inhibitor FR20 | 南京理工大学 | 2018-03-13 | — | — | CN | disclosed |
| CN-104447354-B | A kind of green method that amine derivative is prepared by alkohol and amine | 温州大学 | 2017-06-20 | — | — | CN | disclosed |
| CN-104447354-A | Green method for preparing amine derivatives from alcohols and amines | UNIV WENZHOU | 2015-03-25 | — | — | CN | disclosed |
| US-8604056-B2 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-12-10 | — | — | US | disclosed |
| US-8586617-B2 | Aminomethyl-4-imidazoles | HOFFMANN-LA ROCHE INC. (US) | 2013-11-19 | — | — | US | disclosed |
| CN-102146007-B | Method for preparing secondary amine and tertiary amine | DALIAN CHEMICAL PHYSICS INST | 2013-10-23 | — | — | CN | disclosed |
| CN-101528710-B | Aminomethyl-4-imidazoles | HOFFMANN LA ROCHE | 2012-11-07 | — | — | CN | disclosed |
| US-20120270853-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-10-25 | — | — | US | disclosed |
| US-20080119535-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-22 | — | — | US | disclosed |
| WO-2008046757-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |
| US-20070238751-A1 | Muscarinic Acetylcholine Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | US | disclosed |
| WO-2007070826-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |
| EP-1732923-A2 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099706-A2 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-10-27 | — | — | WO | disclosed |
| EP-1020443-B1 | PROCESS FOR PRODUCING PIPERAZINESULFONAMIDE DERIVATIVES AND SALTS THEREOF | AZWELL INC (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-6172228-B1 | Process for producing piperazinesulfonamide derivatives and salts thereof | AZWELL INC. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-1020443-A1 | PROCESS FOR PRODUCING PIPERAZINESULFONAMIDE DERIVATIVES AND SALTS THEREOF | Azwell Inc. (JP) | 2000-07-19 | — | — | EP | disclosed |
| US-4152452-A | N-BENZYLANILINE AND DERIVATIVES | WILLIAM H. RORER, INC. (US) | 1979-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270853-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | TFPI, F11, F12 | LMNA 655/4885MAOB 589/4885PLA2G1B 1577/4885 |
| US-20080119535-A1 | AMINOMETHYL-4-IMIDAZOLES | INMT, HTR4, MC4R | LMNA 3570/4885MAOB 124/4885PLA2G1B 4539/4885 |
| US-20070238751-A1 | Muscarinic Acetylcholine Receptor Antagonists | CHRM3, CHRNG, CHRM2 | LMNA 4137/4885MAOB 341/4885PLA2G1B 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.