Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 3/20 | 0.38 |
| ▸ | MTTP | P55157 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930954 | 0.91 | POLB (0.39) | APOBMTTPHCRTR1HCRTR2PIK3CD | |
| SCHEMBL2924242 | 0.90 | FABP4 (0.42) | P2RX7HSD11B1HCRTR1HCRTR2PIK3CD | |
| SCHEMBL2931039 | 0.89 | HCRTR2 (0.39) | HCRTR1HCRTR2PIK3CD | |
| SCHEMBL2928147 | 0.88 | HCRTR1 (0.36) | HCRTR1HCRTR2PIK3CDALDH1A1 | |
| SCHEMBL2931914 | 0.86 | HCRTR2 (0.39) | APOBMTTPP2RX7HSD11B1HCRTR1 | |
| SCHEMBL2925490 | 0.86 | PIK3CD (0.37) | HCRTR1HCRTR2PIK3CDALDH1A1 | |
| SCHEMBL2925286 | 0.84 | HCRTR1 (0.44) | HCRTR1HCRTR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3415826 | 0.84 | HCRTR1 (0.44) | HCRTR1HCRTR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL2930742 | 0.83 | PIK3CA (0.35) | HCRTR1HCRTR2PIK3CDALDH1A1 | |
| SCHEMBL2930073 | 0.83 | PDE4B (0.37) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |