Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.34 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.32 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932492 | 0.89 | MKNK1 (0.40) | PIK3CAPIK3CDCYP46A1HCRTR2ALDH1A1 | |
| SCHEMBL2924242 | 0.86 | FABP4 (0.42) | PIK3CAPIK3CDCYP46A1HCRTR2ALDH1A1 | |
| SCHEMBL2930954 | 0.85 | POLB (0.39) | PIK3CAPIK3CDCYP46A1HCRTR2ALDH1A1 | |
| SCHEMBL2930744 | 0.85 | HCRTR2 (0.37) | PIK3CDCYP46A1HCRTR2HCRTR1PRCP | |
| SCHEMBL2931912 | 0.83 | APOB (0.38) | PIK3CDHCRTR2ALDH1A1HCRTR1 | |
| SCHEMBL2931039 | 0.82 | HCRTR2 (0.39) | PIK3CDHCRTR2HCRTR1GRM5 | |
| SCHEMBL2930073 | 0.82 | PDE4B (0.37) | HCRTR2HCRTR1GRM5 | |
| SCHEMBL2928147 | 0.81 | HCRTR1 (0.36) | PIK3CAPIK3CDHCRTR2ALDH1A1HCRTR1 | |
| SCHEMBL2926433 | 0.81 | MGLL (0.38) | PIK3CAPIK3CDHCRTR2ALDH1A1HCRTR1 | |
| SCHEMBL2925490 | 0.80 | PIK3CD (0.37) | PIK3CDHCRTR2ALDH1A1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |