Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | GCK | P35557 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930544 | 0.92 | GHSR (0.36) | LMNAKCNQ1ADORA2AADORA3ADORA1 | |
| SCHEMBL1760902 | 0.88 | ADORA2A (0.43) | LMNAKCNQ1ADORA2AADORA3ADORA1 | |
| SCHEMBL1761046 | 0.85 | ADORA2A (0.39) | LMNAKCNQ1ADORA2AADORA3ADORA1 | |
| SCHEMBL1760889 | 0.80 | ADORA2A (0.43) | ADORA2AADORA3ADORA1MAPTGCK | |
| SCHEMBL2929286 | 0.76 | TNKS (0.39) | — | |
| SCHEMBL2930816 | 0.76 | STAT3 (0.40) | — | |
| SCHEMBL2927299 | 0.75 | PIK3CG (0.36) | ADORA2AADORA1ADORA2B | |
| SCHEMBL3053848 | 0.75 | OGA (0.40) | ADORA2AADORA3ADORA1MAPTSMN1; SMN2 | |
| SCHEMBL2931875 | 0.75 | ALDH1A1 (0.40) | LMNAADORA2AADORA3ADORA1MAPT | |
| SCHEMBL3051009 | 0.74 | OGA (0.36) | ADORA2AADORA3ADORA1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |