Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 12/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761011 | 0.89 | CCR3 (0.46) | STAT3MAPK14CCR3 | |
| SCHEMBL2929995 | 0.87 | ADORA2A (0.37) | CCR3CYP2D6CXCR1CXCR2CCR1 | |
| SCHEMBL2931875 | 0.86 | ALDH1A1 (0.40) | STAT3MAPK14 | |
| SCHEMBL2931791 | 0.86 | RPS6KB1 (0.37) | CCR3CCR5 | |
| SCHEMBL3047619 | 0.79 | RIPK1 (0.37) | KCNH2ACHE | |
| SCHEMBL2927299 | 0.79 | PIK3CG (0.36) | — | |
| SCHEMBL2930809 | 0.78 | LMNA (0.40) | ACHE | |
| SCHEMBL1760975 | 0.78 | CCR3 (0.41) | CCR3 | |
| SCHEMBL2930746 | 0.78 | ACHE (0.40) | ACHE | |
| SCHEMBL1760897 | 0.78 | ADORA2A (0.41) | CCR3CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |