SCHEMBL29322908

SCHEMBL29322908

CC(C)(C)OC(=O)N1CCC(OCC#Cc2cccc3c(C4CCC(=O)NC4=O)coc23)CC1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 13/20 0.47
CRBN Q96SW2 13/20 0.47
GPR119 Q8TDV5 2/20 0.36
PRMT5 O14744 1/20 0.36
WDR77 Q9BQA1 1/20 0.36
NOTCH1 P46531 1/20 0.35
KDM1A O60341 1/20 0.34
PRKCG P05129 1/20 0.34
PRKCB P05771 1/20 0.34
PRKCA P17252 1/20 0.34
PRKCH P24723 1/20 0.34
PRKCE Q02156 1/20 0.34
PRKCD Q05655 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29323432 0.88 DDB1 (0.45) DDB1CRBNGPR119PRMT5WDR77
SCHEMBL29322917 0.87 CRBN (0.39) DDB1CRBN
SCHEMBL29322999 0.84 DDB1 (0.44) DDB1CRBNGPR119
SCHEMBL29323101 0.84 DDB1 (0.44) DDB1CRBNGPR119
SCHEMBL29322910 0.82 CRBN (0.37) DDB1CRBN
SCHEMBL25862159 0.80 DDB1 (0.51) DDB1CRBNPRMT5WDR77KDM1A
SCHEMBL25862452 0.80 DDB1 (0.49) DDB1CRBNGPR119PRMT5WDR77
SCHEMBL29323602 0.80 DDB1 (0.46) DDB1CRBNGPR119PRMT5WDR77
SCHEMBL21997081 0.80 DDB1 (0.42) DDB1CRBNGPR119PRMT5WDR77
SCHEMBL29323213 0.76 DDB1 (0.49) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4400499-A1 GLUTARIMIDE COMPOUND AND USE THEREOF Medshine Discovery Inc. (CN) 2024-07-17 EP disclosed