SCHEMBL29324351

SCHEMBL29324351

CC(C)(C)OC(=O)NCCn1cc(C(=O)O)c(=O)c2cc3c(cc21)OCO3

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.62
KDM4E B2RXH2 2/20 0.62
CYP1A2 P05177 1/20 0.62
CYP2D6 P10635 1/20 0.62
HPGD P15428 1/20 0.62
APEX1 P27695 1/20 0.62
HSD17B10 Q99714 1/20 0.62
TDP1 Q9NUW8 1/20 0.62
PDE4A P27815 1/20 0.47
PDE4B Q07343 1/20 0.47
PDE4C Q08493 1/20 0.47
PDE4D Q08499 1/20 0.47
KMT2A Q03164 2/20 0.45
MEN1 O00255 1/20 0.45
TP53 P04637 4/20 0.44
RXFP1 Q9HBX9 7/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
POLB P06746 3/20 0.42
MAPT P10636 3/20 0.42
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29324341 0.89 KDM4E (0.50) ALDH1A1KDM4ECYP1A2CYP2D6HPGD
SCHEMBL9319939 0.85 ALDH1A1 (0.42) ALDH1A1KDM4ECYP1A2CYP2D6HPGD
SCHEMBL29324375 0.81 PDE4A (0.47) ALDH1A1KDM4ECYP1A2CYP2D6HPGD
SCHEMBL30185626 0.80 ALDH1A1 (0.81) ALDH1A1KDM4ECYP1A2CYP2D6HPGD
SCHEMBL29324307 0.79 LMNA (0.53) LMNA
SCHEMBL27794869 0.79 ALDH1A1 (0.72) ALDH1A1KDM4ECYP1A2CYP2D6HPGD
SCHEMBL11669157 0.79 ALDH1A1 (0.75) ALDH1A1KDM4ECYP1A2CYP2D6HPGD
Oxolinic Acid SCHEMBL24445 0.77 KDM4E (1.00) ALDH1A1KDM4ECYP1A2CYP2D6HPGD
Oxolinic Acid SCHEMBL637058 0.77 KDM4E (1.00) ALDH1A1KDM4ECYP1A2CYP2D6HPGD
Oxolinic Acid SCHEMBL29420856 0.77 KDM4E (1.00) ALDH1A1KDM4ECYP1A2CYP2D6HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151425-A1 COMPOUNDS AND METHOD FOR TREATING HIV INFECTION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-07-18 WO disclosed