Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.46 |
| ▸ | NAMPT | P43490 | 5/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867867 | 0.86 | GPR119 (0.52) | GPR119NAMPTACACB | |
| SCHEMBL21837021 | 0.85 | RORC (0.49) | GPR119NAMPTRORC | |
| SCHEMBL23867869 | 0.85 | MGLL (0.55) | GPR119NAMPTHRH3RORC | |
| SCHEMBL23868051 | 0.84 | ALDH1A1 (0.54) | GPR119NAMPT | |
| SCHEMBL30981442 | 0.83 | NAMPT (0.54) | GPR119NAMPT | |
| SCHEMBL24934709 | 0.82 | GPR119 (0.53) | GPR119NAMPT | |
| SCHEMBL30482767 | 0.81 | GPR119 (0.51) | GPR119NAMPT | |
| SCHEMBL2348870 | 0.81 | GPR119 (0.46) | GPR119NAMPTACACBHRH3 | |
| SCHEMBL23867943 | 0.80 | MGLL (0.50) | GPR119NAMPTHRH3 | |
| SCHEMBL29469965 | 0.80 | MGLL (0.50) | GPR119NAMPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239776-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239776-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPL, LPAR1 | GPR119 254/4885NAMPT 1908/4885ACACB 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.