Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292920 | 0.86 | TLR8 (0.41) | TLR8MCHR1 | |
| SCHEMBL2458695 | 0.85 | MCHR1 (0.30) | MCHR1 | |
| SCHEMBL1389283 | 0.81 | TLR8 (0.37) | TLR8MCHR1GPBAR1 | |
| SCHEMBL2256189 | 0.80 | L3MBTL1 (0.41) | TLR8MCHR1GPBAR1 | |
| SCHEMBL1396371 | 0.78 | LTA4H (0.41) | TLR8MCHR1GPBAR1 | |
| SCHEMBL64412 | 0.77 | ALDH1A1 (0.34) | TLR8 | |
| SCHEMBL6283599 | 0.77 | MCHR1 (0.41) | TLR8MCHR1GPBAR1 | |
| SCHEMBL2458064 | 0.77 | MCHR1 (0.41) | TLR8MCHR1GPBAR1 | |
| SCHEMBL2456698 | 0.77 | MCHR1 (0.41) | TLR8MCHR1GPBAR1 | |
| SCHEMBL2456166 | 0.77 | NCF1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2284169-B1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of CNS disorders | OTSUKA PHARMA CO LTD (JP) | 2012-03-14 | — | — | EP | disclosed |
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |