Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27377729 | 0.90 | PTGES (0.46) | PTGESCYP3A4CYP2C9CYP2C19FEN1 | |
| SCHEMBL29326223 | 0.87 | FEN1 (0.58) | CYP2C9CYP2C19FEN1NPEPPSCDK4 | |
| SCHEMBL29326689 | 0.87 | PTGES (0.48) | PTGESCYP3A4CYP2C9CYP2C19FEN1 | |
| SCHEMBL29326288 | 0.84 | TDP1 (0.49) | PTGESCYP2C9CYP2C19FEN1NPEPPS | |
| SCHEMBL29326300 | 0.83 | KDM4E (0.55) | PTGESFEN1MAPTNPEPPSKDM4E | |
| SCHEMBL29326261 | 0.83 | CYP11B1 (0.47) | CYP3A4CYP2C9CYP2C19NPEPPSCYP11B1 | |
| SCHEMBL29326224 | 0.82 | NPEPPS (0.48) | CYP2C9CYP2C19FEN1NPEPPSKDM4E | |
| SCHEMBL29326295 | 0.81 | KDM4E (0.50) | PTGESFEN1NPEPPSKDM4EALDH1A1 | |
| SCHEMBL29328549 | 0.81 | FEN1 (0.53) | PTGESFEN1MAPTNPEPPSCYP11B1 | |
| SCHEMBL29326246 | 0.81 | METAP2 (0.43) | CYP3A4CYP2C19FEN1NPEPPSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | PTGES 1477/4885CYP3A4 195/4885CYP2C9 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.