Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29328555 | 0.87 | NPC1 (0.52) | KMT2ASMN1; SMN2KDM4EHPGDALDH1A1 | |
| SCHEMBL21756738 | 0.86 | HPGD (0.55) | KMT2ASMN1; SMN2HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL10782201 | 0.85 | ALDH1A1 (0.55) | KMT2AHPGDL3MBTL1ALDH1A1MMP13 | |
| SCHEMBL29328826 | 0.85 | CNR1 (0.48) | KMT2ASMN1; SMN2KDM4EHPGDALDH1A1 | |
| SCHEMBL29328528 | 0.83 | MMP13 (0.60) | KDM4EHPGDALDH1A1HSD17B10THRB | |
| SCHEMBL29328536 | 0.80 | ALDH1A1 (0.47) | KMT2ASMN1; SMN2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL21756722 | 0.80 | EPHX2 (0.55) | SMN1; SMN2KDM4EHPGDALDH1A1 | |
| SCHEMBL21756735 | 0.80 | ALDH1A1 (0.59) | KMT2ASMN1; SMN2L3MBTL1ALDH1A1LMNA | |
| SCHEMBL29328525 | 0.79 | P2RX7 (0.43) | L3MBTL1MAPTMMP13POLB | |
| SCHEMBL10782143 | 0.77 | MAPT (0.54) | SMN1; SMN2KDM4EL3MBTL1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043601-B2 | N-substituted-1H-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2024-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043601-B2 | N-substituted-1H-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same | BAK1, NAAA, CASP3 | KMT2A 299/4885SMN1; SMN2 2714/4885KDM4E 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.