SCHEMBL29328879

SCHEMBL29328879

N=C(/C=C(/Cc1ncc(Cl)cc1F)Nc1ccc(C(F)(F)F)cc1)C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.37
CYP1A2 P05177 2/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C19 P33261 2/20 0.37
ALDH1A1 P00352 3/20 0.36
LMNA P02545 2/20 0.35
GAA P10253 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
MAPT P10636 2/20 0.35
KDM4E B2RXH2 1/20 0.35
POLB P06746 1/20 0.35
HTT P42858 1/20 0.35
CYP2C9 P11712 1/20 0.35
KCNQ3 O43525 1/20 0.34
KCNQ2 O43526 1/20 0.34
KCNE1 P15382 1/20 0.34
KCNQ1 P51787 1/20 0.34
ATF1 P18846 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29328840 0.89 ALDH1A1 (0.38) CYP3A4CYP1A2CYP2D6CYP2C19ALDH1A1
SCHEMBL25711625 0.75 ALDH1A1 (0.37) CYP3A4CYP1A2CYP2D6CYP2C19ALDH1A1
SCHEMBL29329127 0.74 SMN1; SMN2 (0.35) CYP3A4CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL29328867 0.73 ALDH1A1 (0.46) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL29328904 0.71 CYP1A2 (0.45) CYP3A4CYP1A2CYP2C19ALDH1A1LMNA
SCHEMBL14952144 0.66 RAB9A (0.35) CYP3A4CYP1A2CYP2D6CYP2C19ALDH1A1
SCHEMBL29328870 0.65 ALDH1A1 (0.37) ALDH1A1LMNASMN1; SMN2KDM4EKCNQ3
SCHEMBL29328896 0.65 MAPT (0.52) ALDH1A1LMNASMN1; SMN2MEN1KMT2A
SCHEMBL29328911 0.63 ALDH1A1 (0.34) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL23775040 0.62 CNR1 (0.41) MEN1KMT2AKCNQ3KCNQ2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024149676-A1 HERBICIDAL PYRAZOLE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2024-07-18 WO disclosed