SCHEMBL29328870

SCHEMBL29328870

N=C(/C=C(\Nc1ccc(C(F)(F)F)cc1)C(O)c1ncc(F)cc1F)C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.35
LMNA P02545 1/20 0.35
MTOR P42345 1/20 0.34
USP36 Q9P275 1/20 0.33
MAOB P27338 1/20 0.33
EPHX2 P34913 1/20 0.33
TRPV1 Q8NER1 3/20 0.32
TGM2 P21980 1/20 0.32
SIGMAR1 Q99720 1/20 0.31
KDR P35968 3/20 0.31
FLT3 P36888 2/20 0.31
ATF1 P18846 1/20 0.31
NFKB1 P19838 1/20 0.31
KDM4E B2RXH2 1/20 0.31
KCNQ3 O43525 1/20 0.31
KCNQ2 O43526 1/20 0.31
KCNE1 P15382 1/20 0.31
KCNQ1 P51787 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29328840 0.75 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2LMNAMTORUSP36
SCHEMBL29328904 0.72 CYP1A2 (0.45) ALDH1A1SMN1; SMN2LMNATRPV1KDM4E
SCHEMBL29328879 0.65 CYP3A4 (0.37) ALDH1A1SMN1; SMN2LMNAUSP36ATF1
SCHEMBL29328867 0.64 ALDH1A1 (0.46) ALDH1A1LMNAEPHX2TRPV1TGM2
SCHEMBL29328939 0.61 APLNR (0.34) ALDH1A1SMN1; SMN2LMNATGM2KDR
SCHEMBL30999695 0.59 CYP2C9 (0.41) TRPV1
SCHEMBL4966684 0.59 NFKB1 (0.58) SMN1; SMN2LMNAATF1NFKB1KCNQ3
SCHEMBL25991349 0.59 GABRG2 (0.32)
SCHEMBL31064634 0.58 KMT2A (0.46) ALDH1A1SMN1; SMN2LMNAKDM4E
SCHEMBL30134103 0.58 KMT2A (0.46) ALDH1A1SMN1; SMN2LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024149676-A1 HERBICIDAL PYRAZOLE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2024-07-18 WO disclosed