Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 10/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931040 | 0.87 | HCRTR2 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL2930629 | 0.86 | RORB (0.46) | HCRTR1HCRTR2S1PR5 | |
| SCHEMBL2925366 | 0.86 | HCRTR1 (0.39) | HCRTR1HCRTR2S1PR5CHRNA7TRPV1 | |
| SCHEMBL2925423 | 0.86 | CFD (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL2924244 | 0.86 | CYP46A1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL2930074 | 0.85 | SLC6A7 (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL2933414 | 0.85 | HCRTR1 (0.38) | HCRTR1HCRTR2S1PR5CHRNA7TRPV1 | |
| SCHEMBL2928151 | 0.84 | HCRTR2 (0.35) | HCRTR1HCRTR2GRIN2B | |
| SCHEMBL2931914 | 0.84 | HCRTR2 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL2933639 | 0.83 | PAX8 (0.39) | TRPV1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |