Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.46 |
| ▸ | CCR2 | P41597 | 4/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29335243 | 0.90 | ALDH1A1 (0.48) | ALDH1A1MAPTACLYGAAKMT2A | |
| SCHEMBL29335260 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPTACLYGAAKMT2A | |
| SCHEMBL3019464 | 0.83 | CCR2 (0.59) | ACLYCCR2KCNH2POLBHSD17B10 | |
| SCHEMBL29335266 | 0.78 | FABP4 (0.50) | ALDH1A1MAPTACLYGAAKMT2A | |
| SCHEMBL3022491 | 0.77 | PTGES2 (0.52) | ALDH1A1ACLYCCR2FABP4KDM4E | |
| SCHEMBL22492257 | 0.77 | SMN1; SMN2 (0.48) | ALDH1A1MAPTACLYGAAKMT2A | |
| SCHEMBL29335302 | 0.76 | PTGES2 (0.41) | ALDH1A1ACLYKMT2ASLC40A1CCR2 | |
| SCHEMBL3020003 | 0.76 | PTGES2 (0.53) | ACLYCCR2AXLHSD17B10 | |
| SCHEMBL29335270 | 0.76 | ALDH1A1 (0.50) | ALDH1A1MAPTACLYGAAKMT2A | |
| SCHEMBL29335303 | 0.74 | ACLY (0.39) | ALDH1A1ACLYGAASMN1; SMN2SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | NRAS, BRAF, KRAS | ALDH1A1 1786/4885MAPT 3495/4885ACLY 3912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.