Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.45 |
| ▸ | ACLY | P53396 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29335242 | 0.89 | ALDH1A1 (0.50) | ALDH1A1NPSR1MAPTSLC40A1ACLY | |
| SCHEMBL29335243 | 0.86 | ALDH1A1 (0.48) | ALDH1A1NPSR1MAPTSLC40A1ACLY | |
| SCHEMBL29335253 | 0.79 | PTGES2 (0.53) | ALDH1A1SLC40A1ACLYSMN1; SMN2CCR2 | |
| SCHEMBL29335270 | 0.78 | ALDH1A1 (0.50) | ALDH1A1NPSR1MAPTACLYGAA | |
| SCHEMBL29335304 | 0.77 | CCR2 (0.44) | ALDH1A1NPSR1SLC40A1ACLYTP53 | |
| SCHEMBL29335266 | 0.75 | FABP4 (0.50) | ALDH1A1NPSR1MAPTACLYGAA | |
| SCHEMBL3019464 | 0.75 | CCR2 (0.59) | ACLYCCR2PTGES2PIK3CDPIK3CA | |
| SCHEMBL30897292 | 0.74 | PTGES2 (0.61) | SLC40A1ACLYCCR2PTGES2 | |
| Hydrochloric Acid SCHEMBL31588089 | 0.73 | PTGES2 (0.60) | SLC40A1ACLYCCR2PTGES2 | |
| SCHEMBL29335255 | 0.73 | SLC40A1 (0.51) | SLC40A1ACLYCCR2PTGES2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | NRAS, BRAF, KRAS | ALDH1A1 1786/4885NPSR1 3397/4885MAPT 3495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.