Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.36 |
| ▸ | KLK3 | P07288 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CPS1 | P31327 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2925421 | 0.88 | CFD (0.43) | HCRTR1HCRTR2DHODH | |
| SCHEMBL2929167 | 0.88 | KDM4E (0.41) | NPC1HPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2933639 | 0.86 | PAX8 (0.39) | NPC1HPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2924242 | 0.86 | FABP4 (0.42) | HPGDKDM4EALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL2931039 | 0.85 | HCRTR2 (0.39) | PDE4BHCRTR1HCRTR2 | |
| SCHEMBL2930073 | 0.85 | PDE4B (0.37) | SLC9A1PDE4BHCRTR1HCRTR2 | |
| SCHEMBL2931529 | 0.85 | HCRTR1 (0.46) | NPC1HPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2931138 | 0.85 | HCRTR1 (0.40) | NPC1HPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2923504 | 0.83 | PAX8 (0.38) | PAX8TRPV1IKBKBHCRTR1HCRTR2 | |
| SCHEMBL2925366 | 0.83 | HCRTR1 (0.39) | PARP1TRPV1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |