Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923507 | 0.86 | PAX8 (0.39) | PAX8HCRTR2HCRTR1KCNH2TRPV1 | |
| SCHEMBL2924242 | 0.85 | FABP4 (0.42) | HCRTR2HCRTR1 | |
| SCHEMBL2930073 | 0.85 | PDE4B (0.37) | HCRTR2HCRTR1 | |
| SCHEMBL2931039 | 0.85 | HCRTR2 (0.39) | HCRTR2HCRTR1 | |
| SCHEMBL2933638 | 0.83 | NPC1 (0.39) | PAX8HCRTR2HCRTR1TRPV1SCD5 | |
| SCHEMBL2925366 | 0.82 | HCRTR1 (0.39) | HCRTR2HCRTR1TRPV1 | |
| SCHEMBL2930954 | 0.82 | POLB (0.39) | HCRTR2HCRTR1 | |
| SCHEMBL2928147 | 0.82 | HCRTR1 (0.36) | HCRTR2HCRTR1GRIN2B | |
| SCHEMBL2931912 | 0.80 | APOB (0.38) | HCRTR2HCRTR1 | |
| SCHEMBL2925421 | 0.80 | CFD (0.43) | HCRTR2HCRTR1CSNK1ENOTUMUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |