Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.51 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | COMT | P21964 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205874 | 0.93 | ESR1 (0.49) | ESR1TSHRLMNACYP1A2CYP2C19 | |
| SCHEMBL2935502 | 0.93 | ESR1 (0.49) | ESR1TSHRLMNACYP1A2CYP2C19 | |
| Protiofate SCHEMBL871311 | 0.88 | MAPT (0.50) | ESR1TSHRLMNACYP1A2CYP2C19 | |
| Protiofate SCHEMBL5378233 | 0.81 | MAPT (0.45) | ESR1TSHRLMNASMN1; SMN2TDP1 | |
| SCHEMBL1141274 | 0.79 | GAA (0.56) | TSHRLMNACYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL11099233 | 0.79 | ALDH1A1 (0.48) | TSHRCYP1A2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6231662 | 0.78 | ESR1 (0.52) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL11095728 | 0.78 | GAA (0.50) | TSHRSMN1; SMN2ALDH1A1CYP3A4KDM4E | |
| SCHEMBL10923446 | 0.78 | MAPT (0.56) | ESR1TSHRLMNATDP1ALDH1A1 | |
| SCHEMBL1726035 | 0.78 | GAA (0.55) | TSHRLMNACYP1A2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461341-B1 | PROCESS FOR PREPARING A HETEROAROMATIC COMPOUND SUBSTITUTED WITH ONE OR MORE ETHER GROUPS | AGFA GEVAERT (BE) | 2010-01-27 | — | — | EP | disclosed |
| US-6734312-B2 | CONDENSING HYDROXY- GROUP OF A COMPOUND HAVING HETEROAROMATIC NUCLEUS, WITH AN ALCOHOL CONTAINING ONE OR MORE PRIMARY OR SECONDARY ALCOHOL GROUPS, OPTIONALLY USING THE REDOX COUPLE OF A TRIARYL- OR TRIALKYLPHOSPHINE AND AN AZODIOXO-COMPOUND | AGFA-GEVAERT (BE) | 2004-05-11 | — | — | US | disclosed |
| US-20030162958-A1 | Process for preparing a compound containing a heteroaromatic group with one or more ether substituents | AGFA-GEVAERT (BE) | 2003-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162958-A1 | Process for preparing a compound containing a heteroaromatic group with one or more ether substituents | ADH1C, ADH1A, CYP2E1 | ESR1 1160/4885TSHR 1485/4885LMNA 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.