Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537835 | 0.87 | KIF11 (0.45) | KIF11ERAP1PARP14TP53MAPT | |
| SCHEMBL3393216 | 0.83 | MAPT (0.39) | KIF11ERAP1PARP14TP53MAPT | |
| SCHEMBL2429422 | 0.81 | PARP14 (0.51) | KIF11PARP14TP53MAPTPIM1 | |
| SCHEMBL4786156 | 0.81 | SLC22A6 (0.55) | KIF11PARP14TP53MAPTPIM1 | |
| SCHEMBL27500727 | 0.81 | PARP14 (0.49) | KIF11PARP14TP53MAPTPIM1 | |
| SCHEMBL3924071 | 0.80 | PARP14 (0.50) | KIF11ERAP1PARP14TP53MAPT | |
| SCHEMBL15560416 | 0.79 | KIF11 (0.47) | KIF11PARP14TP53MAPTPIM1 | |
| SCHEMBL6601301 | 0.79 | PARP14 (0.51) | KIF11ERAP1PARP14TP53MAPT | |
| Sulfuric Acid SCHEMBL11525433 | 0.79 | MAPT (0.36) | KIF11ERAP1PARP14TP53MAPT | |
| SCHEMBL29001995 | 0.78 | KIF11 (0.44) | KIF11ERAP1PARP14TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229399-A1 | INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES AND METHODS OF USE THEREOF | Provid Pharmaceuticals, Inc. (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009073168-A1 | INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES AND METHODS OF USE THEREOF | PROVID PHARMACEUTICALS, INC. (US) | 2009-06-11 | — | — | WO | disclosed |
| EP-1605963-A4 | INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES AND METHODS OF USE THEREOF | PROVID PHARMACEUTICALS INC (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1605963-A2 | INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES AND METHODS OF USE THEREOF | Provid Pharmaceuticals, Inc. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004073625-A2 | INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES AND METHODS OF USE THEREOF | PROVID PHARMACEUTICALS, INC. (US) | 2004-09-02 | — | — | WO | disclosed |