Neurotensin

Neurotensin

SCHEMBL29357707

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ NTSR1 P30989 11/20 0.70
▸ NTSR2 O95665 5/20 0.70
▸ NPY1R P25929 1/20 0.65
▸ SORT1 Q99523 4/20 0.65
▸ OPRD1 P41143 2/20 0.64
▸ OPRM1 P35372 1/20 0.64
▸ OPRK1 P41145 1/20 0.64
▸ HCRTR1 O43613 1/20 0.64
▸ HCRTR2 O43614 1/20 0.64
▸ NMUR2 Q9GZQ4 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Neurotensin SCHEMBL29851748 1.00 NTSR1 (0.70) NTSR1NTSR2NPY1RSORT1OPRD1
SCHEMBL30102522 0.98 NTSR1 (0.70) NTSR1NTSR2NPY1RSORT1OPRD1
SCHEMBL30446151 0.94 NMUR2 (0.67) NTSR1NTSR2NPY1RNMUR2
SCHEMBL30957024 0.92 KDM1A (0.61) NTSR1NTSR2NPY1RSORT1
Neurotensin SCHEMBL30483709 0.92 KDM1A (0.61) NTSR1NTSR2NPY1RSORT1
SCHEMBL29361023 0.86 NTSR1 (0.74) NTSR1NTSR2SORT1OPRD1OPRM1
SCHEMBL29402893 0.86 HCRTR1 (0.68) NTSR1NPY1ROPRD1OPRM1OPRK1
SCHEMBL31302260 0.86 KDM1A (0.58) NPY1ROPRD1
SCHEMBL38650581 0.86 KDM1A (0.62) NPY1ROPRM1OPRK1NMUR2
SCHEMBL29930119 0.84 NTSR1 (0.87) NTSR1NTSR2NPY1RSORT1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2384 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116036309-B Layered double hydroxide material system and preparation method and application thereof Shanghai Teyijie Biotechnology Co.,Ltd. (CN) 2026-05-26 — — CN claimed
WO-2026090085-A1 TREATMENT OF CD33 RELATED DISEASES AND DISORDERS EMPIRICO INC. (US) 2026-04-30 — — WO claimed
EP-3532092-B1 IMMUNOGLOBULINS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2026-04-29 — — EP claimed
US-12611379-B2 Lipid nano drug delivery system targeting brain lesion and preparation method and application thereof SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE (CN) 2026-04-28 — — US claimed
EP-4728279-A2 USE OF CUSTOM-DESIGNED PEPTIDES FOR MASS CALIBRATION DH Technologies Development Pte. Ltd. (SG) 2026-04-22 — — EP claimed
US-20260083820-A1 METHOD FOR AMELIORATING AUTISM SYMPTOMS BY PHARMACOLOGICAL ACTIVATION OF THE NEUROTENSIN RECEPTOR 1 (NTSR1) NEW YORK INSTITUTE OF TECHNOLOGY (US) 2026-03-26 — — US claimed
EP-4688849-A1 BLOOD-BRAIN BARRIER CROSSING ANTIBODIES VIB VZW (BE) 2026-02-11 — — EP claimed
US-12474353-B2 Methods and materials for assessing and treating obesity MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2025-11-18 — — US claimed
WO-2025235433-A1 ENGINEERED MICROBES AS DELIVERY VEHICLES OF MODULATORY MOLECULES OF THE ENTEROENDOCRINE SYSTEM PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2025-11-13 — — WO claimed
US-20250345446-A1 BIFUNCTIONAL MOLECULES THAT SELECTIVELY INDUCE DEGRADATION OF EXTRACELLULAR TARGETS IN LYSOSOMES DRAUPNIR BIO APS (DK) 2025-11-13 — — US claimed
US-20220133839-A1 PEPTIDE ANALOGUES WITH BRANCHED AMINO ACID PROBE(S) TXP PHARMA GMBH (CH) 2022-05-05 — — US claimed
EP-3988580-A2 HYDROGEL INCLUSION COMPLEX CONTAINING BIOACTIVE SUBSTANCE BOUND TO TEMPERATURE-SENSITIVE POLYPHOSPHAZENE BY HOST-GUEST INTERACTION THROUGH BETA-CYCLODEXTRIN, AND USE THEREOF Korea Institute of Science and Technology (KR) 2022-04-27 — — EP claimed
CN-114306547-A Traditional Chinese medicine formula for regulating and controlling intestinal function of pregnant women 华子昂 2022-04-12 — — CN claimed
CN-114306550-A Traditional Chinese medicine formula for regulating and controlling intestinal function of perimenopausal women 刘敏如女科医系研究院(深圳)有限公司 2022-04-12 — — CN claimed
CN-114272323-A Traditional Chinese medicine formula for regulating and controlling intestinal function of lactating women 华子昂 2022-04-05 — — CN claimed
CN-114272321-A Traditional Chinese medicine formula for regulating and controlling intestinal function of old people 华子昂 2022-04-05 — — CN claimed
CN-114272335-A Traditional Chinese medicine formula for regulating and controlling intestinal function of children 华子昂 2022-04-05 — — CN claimed
CN-114269391-A Hydrogel inclusion complexes comprising physiologically active substances bound to thermosensitive poly (phosphazene) through host-guest interactions using beta-cyclodextrin and uses thereof 韩国科学技术研究院 2022-04-01 — — CN claimed
US-11261164-B2 Small molecule agonists of neurotensin receptor 1 Sanford Burnham Prebys Medical Discovery Institute (US) 2022-03-01 — — US claimed
WO-2022032353-A1 RADIOPHARMACEUTICALS, USES THEREOF, AND METHODS FOR THE PRODUCTION THEREOF Clarity Pharmaceuticals Ltd (AU) 2022-02-17 — — WO claimed
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