Neurotensin

Neurotensin

SCHEMBL29851748

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCC(=O)O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C1CCC(=O)N1)C(=O)NC(CC(C)C)C(=O)O

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ NTSR1 P30989 11/20 0.70
▸ NTSR2 O95665 5/20 0.70
▸ NPY1R P25929 1/20 0.65
▸ SORT1 Q99523 4/20 0.65
▸ OPRD1 P41143 2/20 0.64
▸ OPRM1 P35372 1/20 0.64
▸ OPRK1 P41145 1/20 0.64
▸ HCRTR1 O43613 1/20 0.64
▸ HCRTR2 O43614 1/20 0.64
▸ NMUR2 Q9GZQ4 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Neurotensin SCHEMBL29357707 1.00 NTSR1 (0.70) NTSR1NTSR2NPY1RSORT1OPRD1
SCHEMBL30102522 0.98 NTSR1 (0.70) NTSR1NTSR2NPY1RSORT1OPRD1
SCHEMBL30446151 0.94 NMUR2 (0.67) NTSR1NTSR2NPY1RNMUR2
SCHEMBL30957024 0.92 KDM1A (0.61) NTSR1NTSR2NPY1RSORT1
Neurotensin SCHEMBL30483709 0.92 KDM1A (0.61) NTSR1NTSR2NPY1RSORT1
SCHEMBL29361023 0.86 NTSR1 (0.74) NTSR1NTSR2SORT1OPRD1OPRM1
SCHEMBL29402893 0.86 HCRTR1 (0.68) NTSR1NPY1ROPRD1OPRM1OPRK1
SCHEMBL31302260 0.86 KDM1A (0.58) NPY1ROPRD1
SCHEMBL38650581 0.86 KDM1A (0.62) NPY1ROPRM1OPRK1NMUR2
SCHEMBL29930119 0.84 NTSR1 (0.87) NTSR1NTSR2NPY1RSORT1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025227105-A1 CLEAVABLE LINKERS WITH TUNABLE HALF-LIVES UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2025-10-30 — — WO disclosed
US-20240269293-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD THERAPEUTICS LIMITED (CN) 2024-08-15 — — US disclosed
EP-4313154-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD Therapeutics Limited (HK) 2024-02-07 — — EP disclosed
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF AJ SCIENCES (YIXING) CO., LTD (CN) 2022-12-22 — — US disclosed
WO-2022212362-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) 2022-10-06 — — WO disclosed
EP-4037715-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF Beijing Xuanyi Pharmasciences Co., Ltd. (CN) 2022-08-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240269293-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF CD44, MACROD1, MSN NTSR1 3864/4885NTSR2 4082/4885NPY1R 4021/4885
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF CD44, SSB, DNPEP NTSR1 3916/4885NTSR2 4097/4885NPY1R 4034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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