Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAA50 | Q9GZZ1 | 2/20 | 0.84 |
| ▸ | CHAT | P28329 | 2/20 | 0.81 |
| ▸ | EP300 | Q09472 | 3/20 | 0.79 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.79 |
| ▸ | AURKA | O14965 | 2/20 | 0.79 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.79 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20857028 | 1.00 | NAA50 (0.84) | NAA50CHATEP300KAT5AURKA | |
| SCHEMBL218619 | 1.00 | NAA50 (0.84) | NAA50CHATEP300KAT5AURKA | |
| SCHEMBL285428 | 0.97 | NAA50 (0.84) | NAA50CHATEP300KAT5AURKA | |
| SCHEMBL19181359 | 0.97 | NAA50 (0.83) | NAA50CHATEP300KAT5AURKA | |
| SCHEMBL420710 | 0.96 | NAA50 (0.85) | NAA50CHATEP300KAT5AURKA | |
| Succinyl-Coa SCHEMBL4360979 | 0.96 | NAA50 (0.87) | NAA50CHATEP300KAT5AURKA | |
| Succinyl-Coa SCHEMBL31385487 | 0.96 | NAA50 (0.87) | NAA50CHATEP300KAT5AURKA | |
| Succinyl-Coa SCHEMBL4364428 | 0.96 | NAA50 (0.87) | NAA50CHATEP300KAT5AURKA | |
| Succinyl-Coa SCHEMBL4360968 | 0.96 | NAA50 (0.87) | NAA50CHATEP300KAT5AURKA | |
| Succinyl-Coa SCHEMBL50744 | 0.96 | NAA50 (0.87) | NAA50CHATEP300KAT5AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260028651-A1 | METHOD OF PRODUCING & PROCESSING DIAMINES | AGAIN BIO APS (DK) | 2026-01-29 | — | — | US | disclosed |
| US-12529078-B2 | Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis | GENOMATICA, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12503711-B2 | Method of producing and processing diamines to a diamine free base using a carbonate intermediate and an engineered microorganism | GENOMATICA, INC. (US) | 2025-12-23 | — | — | US | disclosed |
| US-20240294950-A1 | MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS | AGAIN BIO APS (DK) | 2024-09-05 | — | — | US | disclosed |
| EP-4421181-A2 | NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY | Genomatica, Inc. (US) | 2024-08-28 | — | — | EP | disclosed |
| EP-3741865-B1 | NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY | GENOMATICA INC (US) | 2024-03-13 | — | — | EP | disclosed |
| US-11834690-B2 | Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid | GENOMATICA, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| EP-4273255-A2 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF HEXAMETHYLENEDIAMINE | Genomatica, Inc. (US) | 2023-11-08 | — | — | EP | disclosed |
| US-20230332194-A1 | MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING ADIPATE, 6-AMINOCAPROATE, HEXAMETHYLENEDIAMINE OR CAPROLACTAM RELATED THERETO | GENOMATICA INC (US) | 2023-10-19 | — | — | US | disclosed |
| US-11753663-B2 | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto | GENOMATICA, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11702682-B2 | Method of producing and processing diamines to a diamine free base using a carbonate intermediate and an engineered microorganism | GENOMATICA, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| EP-3611254-B1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF HEXAMETHYLENEDIAMINE | GENOMATICA INC (US) | 2023-07-05 | — | — | EP | disclosed |
| US-20230126921-A1 | NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY | AGAIN BIO APS (DK) | 2023-04-27 | — | — | US | disclosed |
| US-20230022727-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID | GENOMATICA INC (US) | 2023-01-26 | — | — | US | disclosed |
| US-11447804-B2 | Producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam in the presence of methanol using a microorganism having increased availability of reducing equivalents | GENOMATICA, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| US-20220220511-A1 | MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY FORMATE ASSIMILATION | GENOMATICA INC (US) | 2022-07-14 | — | — | US | disclosed |
| US-20220056488-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF AROMATICS, 2,4-PENTADIENOATE AND 1,3-BUTADIENE | GENOMATICA INC (US) | 2022-02-24 | — | — | US | disclosed |
| US-20220025411-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE | GENOMATICA INC (US) | 2022-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12529078-B2 | Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis | ALDOA, FDPS, DERA | NAA50 298/4885CHAT 1363/4885EP300 1390/4885 |
| US-20260028651-A1 | METHOD OF PRODUCING & PROCESSING DIAMINES | DDC, DAO, ODC1 | NAA50 69/4885CHAT 77/4885EP300 1948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.