Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | VEGFA | P15692 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MGLL | Q99685 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11900867 | 0.78 | MPO (0.59) | ALDH1A1SMN1; SMN2VEGFAEGLN1CHRM2 | |
| SCHEMBL23293544 | 0.77 | ACHE (0.60) | ALDH1A1VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL30422174 | 0.77 | ACHE (0.60) | ALDH1A1VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL16830462 | 0.77 | ACHE (0.60) | ALDH1A1VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL6140255 | 0.77 | VEGFA (0.53) | ALDH1A1SMN1; SMN2VEGFAEGLN1CHRM2 | |
| SCHEMBL15264216 | 0.77 | MGLL (0.55) | ALDH1A1VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL3847987 | 0.77 | POLB (0.52) | ALDH1A1VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL9933216 | 0.77 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2VEGFAEGLN1CHRM2 | |
| SCHEMBL17276773 | 0.77 | ALDH1A1 (0.72) | ALDH1A1VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL376336 | 0.77 | ALDH1A1 (0.60) | ALDH1A1VEGFAEGLN1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |