Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Calothrixin B SCHEMBL5222737 | 1.00 | CDK4 (0.45) | CDK4CCND1TOP2AIDO1ALDH1A1 | |
| SCHEMBL1103721 | 0.79 | MEN1 (0.44) | IDO1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL21561768 | 0.79 | ALDH1A1 (0.56) | CDK4CCND1ALDH1A1KDM4EHPGD | |
| SCHEMBL16895263 | 0.76 | DNMT1 (0.46) | IDO1ALDH1A1KDM4EMAPTLMNA | |
| Benzocarbazoledione SCHEMBL22541347 | 0.76 | MAOA (0.54) | CDK4CCND1ALDH1A1KDM4EHPGD | |
| SCHEMBL459050 | 0.73 | KMT2A (0.44) | IDO1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL29641696 | 0.73 | KMT2A (0.44) | IDO1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL22541429 | 0.72 | CDC25B (0.44) | CDK4CCND1TOP2AALDH1A1KDM4E | |
| SCHEMBL6503650 | 0.72 | MAOA (0.54) | CDK4CCND1ALDH1A1KDM4EHPGD | |
| SCHEMBL30673946 | 0.72 | MAOA (0.54) | CDK4CCND1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947333-A4 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES- CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | Council of Scientific & Industrial Research (IN) | 2022-12-28 | — | — | EP | disclosed |
| EP-3947333-A1 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES- CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | Council of Scientific & Industrial Research (IN) | 2022-02-09 | — | — | EP | disclosed |
| EP-3947333-A1 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES- CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | Council of Scientific & Industrial Research (IN) | 2022-02-09 | — | — | EP | disclosed |