Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Calothrixin B SCHEMBL29375353 | 1.00 | CDK4 (0.45) | CDK4CCND1TOP2AIDO1ALDH1A1 | |
| SCHEMBL1103721 | 0.79 | MEN1 (0.44) | IDO1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL21561768 | 0.79 | ALDH1A1 (0.56) | CDK4CCND1ALDH1A1KDM4EHPGD | |
| SCHEMBL16895263 | 0.76 | DNMT1 (0.46) | IDO1ALDH1A1KDM4EMAPTLMNA | |
| Benzocarbazoledione SCHEMBL22541347 | 0.76 | MAOA (0.54) | CDK4CCND1ALDH1A1KDM4EHPGD | |
| SCHEMBL459050 | 0.73 | KMT2A (0.44) | IDO1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL29641696 | 0.73 | KMT2A (0.44) | IDO1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL22541429 | 0.72 | CDC25B (0.44) | CDK4CCND1TOP2AALDH1A1KDM4E | |
| SCHEMBL6503650 | 0.72 | MAOA (0.54) | CDK4CCND1ALDH1A1KDM4EHPGD | |
| SCHEMBL30673946 | 0.72 | MAOA (0.54) | CDK4CCND1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169609-A1 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES, CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-06-02 | — | — | US | claimed |
| EP-3947333-A1 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES- CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | Council of Scientific & Industrial Research (IN) | 2022-02-09 | — | — | EP | claimed |
| WO-2020202180-A1 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES- CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-10-08 | — | — | WO | claimed |
| US-12459893-B2 | Indole-ynone mediated benzoannulation process for the preparation of carbazoles, carbazomycin A, calothrixin B and staurosporinone | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2025-11-04 | — | — | US | disclosed |
| US-12459893-B2 | Indole-ynone mediated benzoannulation process for the preparation of carbazoles, carbazomycin A, calothrixin B and staurosporinone | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2025-11-04 | — | — | US | disclosed |
| US-12459893-B2 | Indole-ynone mediated benzoannulation process for the preparation of carbazoles, carbazomycin A, calothrixin B and staurosporinone | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2025-11-04 | — | — | US | disclosed |
| US-11834458-B2 | Anti-cancer nuclear hormone receptor-targeting compounds | NUVATION BIO INC. (US) | 2023-12-05 | — | — | US | disclosed |
| EP-3947333-A4 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES- CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | Council of Scientific & Industrial Research (IN) | 2022-12-28 | — | — | EP | disclosed |
| US-11421223-B2 | Processes and host cells for genome, pathway, and biomolecular engineering | ENEVOLV, INC. (US) | 2022-08-23 | — | — | US | disclosed |
| US-20220169609-A1 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES, CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-06-02 | — | — | US | disclosed |
| US-20220169609-A1 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES, CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-06-02 | — | — | US | disclosed |
| US-20180320170-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | ENEVOLV, INC. | 2018-11-08 | — | — | US | disclosed |
| US-9944925-B2 | Processes and host cells for genome, pathway, and biomolecular engineering | ENEVOLV, INC. | 2018-04-17 | — | — | US | disclosed |
| US-20160186168-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | ENEVOLV, INC. | 2016-06-30 | — | — | US | disclosed |
| EP-1178988-B1 | COMPOUNDS AND THERAPEUTIC METHODS | UNIV AUSTRALIAN (AU) | 2007-02-28 | — | — | EP | disclosed |
| EP-1178988-B1 | COMPOUNDS AND THERAPEUTIC METHODS | UNIV AUSTRALIAN (AU) | 2007-02-28 | — | — | EP | disclosed |
| EP-1178988-A4 | COMPOUNDS AND THERAPEUTIC METHODS | UNIV AUSTRALIAN (AU) | 2004-10-06 | — | — | EP | disclosed |
| US-6632822-B1 | Indolo(3,2-j)phenanthridine compounds; anticancer agents, malaria | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 2003-10-14 | — | — | US | disclosed |
| EP-1178988-A1 | COMPOUNDS AND THERAPEUTIC METHODS | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000069856-A1 | COMPOUNDS AND THERAPEUTIC METHODS | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12459893-B2 | Indole-ynone mediated benzoannulation process for the preparation of carbazoles, carbazomycin A, calothrixin B and staurosporinone | CYC1, CYCS, CANX | CDK4 534/4885CCND1 1029/4885TOP2A 697/4885 |
| US-11834458-B2 | Anti-cancer nuclear hormone receptor-targeting compounds | NCOA1, NCOR1, NCOA3 | CDK4 169/4885CCND1 1546/4885TOP2A 295/4885 |
| US-20220169609-A1 | INDOLE-YNONE MEDIATED BENZOANNULATION PROCESS FOR THE PREPARATION OF CARBAZOLES, CARBAZOMYCIN A, CALOTHRIXIN B AND STAUROSPORINONE | CYC1, CYCS, CANX | CDK4 534/4885CCND1 1029/4885TOP2A 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.