Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 7/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.50 |
| ▸ | HTR1B | P28222 | 3/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1100989 | 0.81 | RAB9A (0.60) | KDM4EALDH1A1HPGDABCB1HTR1A | |
| SCHEMBL28898625 | 0.80 | FFAR1 (0.42) | NISCHKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL21199319 | 0.77 | SMN1; SMN2 (0.66) | KDM4EALDH1A1HPGDTDP1ABCB1 | |
| SCHEMBL1004347 | 0.77 | CYSLTR1 (0.61) | KCNA3HTR1B | |
| SCHEMBL21795756 | 0.77 | SYK (0.60) | KDM4EALDH1A1HPGDTDP1ABCB1 | |
| SCHEMBL5789318 | 0.76 | ALDH1A1 (0.55) | NISCHKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL9574720 | 0.76 | HTR1B (0.58) | NISCHKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL9574725 | 0.76 | MAPT (0.67) | NISCHKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL31473925 | 0.75 | MAOA (0.51) | KDM4EALDH1A1HPGDABCB1HTR1A | |
| SCHEMBL9770352 | 0.75 | KCNA3 (0.81) | TDP1MEN1KMT2AKCNA3HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790723-B2 | Thiazole derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2010-09-07 | — | — | US | disclosed |
| EP-1343769-B1 | BENZOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2010-08-04 | — | — | EP | disclosed |
| EP-1511737-B1 | ARYLOXIMES | MERCK PATENT GMBH (DE) | 2010-02-17 | — | — | EP | disclosed |
| EP-1509506-B1 | PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| US-7563790-B2 | Pyridazine derivatives | MERCK PATENT GMBH (DE) | 2009-07-21 | — | — | US | disclosed |
| US-7544684-B2 | Hydrazono-malonitriles | MERCK PATENT GMBH (DE) | 2009-06-09 | — | — | US | disclosed |
| US-7498334-B2 | Pyrrolopyrimidines as phosphodiesterase VII inhibitors | MERCK PATENT GMBH (DE) | 2009-03-03 | — | — | US | disclosed |
| US-7470687-B2 | Aryl oximes | MERCK PATENT GMBH (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7354941-B2 | Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of PDE4 isozymes | PFIZER PRODUCTS INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7312328-B2 | Benzoylpyridazines | MERCK PATENT GMBH (DE) | 2007-12-25 | — | — | US | disclosed |
| EP-1252157-A1 | PYRIMIDINE CARBOXAMIDES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | Pfizer Products Inc. (US) | 2002-10-30 | — | — | EP | disclosed |
| US-20020123520-A1 | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC. | 2002-09-05 | — | — | US | disclosed |
| US-20020111495-A1 | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes | PFIZER INC. | 2002-08-15 | — | — | US | disclosed |
| WO-2002060875-A1 | NICOTINAMIDE BIARYL DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2002-08-08 | — | — | WO | disclosed |
| WO-2002060896-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2002-08-08 | — | — | WO | disclosed |
| WO-2002060898-A1 | THIAZOLYL-, OXAZOLYL-, PYRROLYL-, AND IMIDAZOLYL-ACID AMIDE DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2002-08-08 | — | — | WO | disclosed |
| EP-1229034-A1 | Nicotinamide derivatives and their mimetics as inhibitors of PDE4 isozymes | Pfizer Products Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2002051814-A1 | BENZOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2002-07-04 | — | — | WO | disclosed |
| WO-2001057025-A1 | PYRIMIDINE CARBOXAMIDES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2001-08-09 | — | — | WO | disclosed |
| WO-2001057036-A1 | NICOTINAMIDE BENZOFUSED-HETEROCYCLYL DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020123520-A1 | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes | CBR1, CBR3, PDE4A | NISCH 4565/4885KDM4E 3107/4885ALDH1A1 434/4885 |
| US-20020111495-A1 | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes | NOX3, NOX1, NOX4 | NISCH 2349/4885KDM4E 1270/4885ALDH1A1 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.