Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | KDM1A | O60341 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 1.00 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 1.00 |
| ▸ | IDO1 | P14902 | 2/20 | 0.76 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.74 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.74 |
| ▸ | ACHE | P22303 | 7/20 | 0.67 |
| ▸ | EP300 | Q09472 | 5/20 | 0.67 |
| ▸ | BCHE | P06276 | 5/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29595926 | 0.92 | KDM1A (0.85) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| Coptisine SCHEMBL31392604 | 0.86 | IDO1 (1.00) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| Coptisine SCHEMBL156866 | 0.86 | IDO1 (1.00) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| Coptisine SCHEMBL29931632 | 0.86 | IDO1 (1.00) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| Coptisine SCHEMBL154528 | 0.85 | METTL3 (1.00) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| Coptisine SCHEMBL2441815 | 0.85 | IDO1 (0.98) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| Columbamine SCHEMBL7604369 | 0.84 | CYP3A4 (0.78) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| SCHEMBL26620431 | 0.84 | ALDH1A1 (0.72) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| Coptisine SCHEMBL8858972 | 0.80 | IDO1 (0.87) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A | |
| Berberine SCHEMBL15669190 | 0.80 | ACHE (1.00) | MAPTLMNAALDH1A1SMN1; SMN2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116687924-A | Application of berberine and derivatives thereof | 中国医学科学院药物研究所 | 2023-09-05 | — | — | CN | disclosed |
| CN-115813983-A | Preparation method and application of coptis and magnolia officinalis high-efficiency extract and microemulsion thereof | 成都大学 | 2023-03-21 | — | — | CN | disclosed |
| CN-115666636-A | Delivery of gene expression modulators for treatment of cancer and viral infections | 中佛罗里达大学研究基金会有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-112851661-B | Method for modularly and diversely synthesizing benzophenanthridine and protoberberine alkaloids | 华东师范大学 | 2022-12-06 | — | — | CN | disclosed |
| CN-114504651-A | Antibodies, uses and methods | 科马布有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-114504652-A | Antibodies, uses and methods | 科马布有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-108064169-B | Antibodies, uses and methods | 科马布有限公司 | 2022-02-11 | — | — | CN | disclosed |
| CN-114018838-A | Method for measuring total alkaloid content in traditional Chinese medicine preparation | 汕头市美宝制药有限公司 | 2022-02-08 | — | — | CN | disclosed |