Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Coptisine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE known ✓ | P06276 | 9/20 | 0.64 |
| ▸ | ACHE known ✓ | P22303 | 9/20 | 0.64 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.64 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.64 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.64 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.64 |
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.64 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.64 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.64 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.64 |
| ▸ | IDO1 | P14902 | 2/20 | 0.98 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.95 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KDM1A | O60341 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Coptisine SCHEMBL156866 | 0.99 | IDO1 (1.00) | IDO1METTL3METTL14ALDH1A1LMNA | |
| Coptisine SCHEMBL29931632 | 0.99 | IDO1 (1.00) | IDO1METTL3METTL14ALDH1A1LMNA | |
| Coptisine SCHEMBL31392604 | 0.99 | IDO1 (1.00) | IDO1METTL3METTL14ALDH1A1LMNA | |
| Coptisine SCHEMBL154528 | 0.98 | METTL3 (1.00) | IDO1METTL3METTL14ALDH1A1LMNA | |
| Coptisine SCHEMBL8858972 | 0.92 | IDO1 (0.87) | IDO1METTL3METTL14ALDH1A1LMNA | |
| SCHEMBL26159296 | 0.89 | IDO1 (0.82) | IDO1METTL3METTL14ALDH1A1LMNA | |
| Coptisine SCHEMBL158088 | 0.88 | METTL3 (0.82) | IDO1METTL3METTL14ALDH1A1LMNA | |
| Coptisine SCHEMBL16279007 | 0.87 | METTL3 (0.79) | IDO1METTL3METTL14ALDH1A1LMNA | |
| SCHEMBL29378641 | 0.85 | MAPT (1.00) | IDO1METTL3METTL14ALDH1A1LMNA | |
| SCHEMBL2882394 | 0.82 | CYP1B1 (0.74) | IDO1METTL3METTL14ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119950498-A | Application of coptisine hydrochloride in preparation of HMGB3 inhibitor | 哈尔滨医科大学 | 2025-05-09 | — | — | CN | claimed |
| CN-115684437-B | Construction method and application of finger print of long qing preparation | 津药达仁堂集团股份有限公司隆顺榕制药厂 | 2025-04-22 | — | — | CN | claimed |
| CN-119656183-A | Application of effective ingredient formula of known cellulitis in treating peripheral neuropathy caused by diabetes | 唐宁医药科技(济南)有限公司 | 2025-03-21 | — | — | CN | claimed |
| CN-119643725-A | Construction method and application of celandine sample characteristic spectrum | 江阴天江药业有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119234839-A | Application of coptis chinensis water extract in preparation of biopesticide for inhibiting black spore mold | 南京中医药大学 | 2025-01-03 | — | — | CN | claimed |
| CN-118925690-B | Application of metal organic frame material in selectively fishing traditional Chinese medicine active ingredients | 山东中医药大学 | 2024-12-24 | — | — | CN | claimed |
| CN-118925690-A | Application of metal organic frame material in selectively fishing traditional Chinese medicine active ingredients | 山东中医药大学 | 2024-11-12 | — | — | CN | claimed |
| CN-118583992-A | UPLC fingerprint of traditional Chinese medicine compound and construction method and application thereof | 生猪技术创新中心(重庆) | 2024-09-03 | — | — | CN | claimed |
| CN-118416085-A | Pharmaceutical composition for treating gastroesophageal reflux disease and application thereof | 黑龙江珍宝岛药业股份有限公司 | 2024-08-02 | — | — | CN | claimed |
| CN-116626199-B | Method for measuring content of 10 components in Angong bezoar pills | 山东宏济堂制药集团股份有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-111480654-B | Application of coptisine substances as herbicide | 华南农业大学 | 2021-06-15 | — | — | CN | claimed |
| CN-112618718-A | Substance for improving killing power of immune cells and preparation and application thereof | 邯郸制药股份有限公司 | 2021-04-09 | — | — | CN | claimed |
| CN-108226321-B | Fingerprint detection method and fingerprint of fructus piperis longi and fructus piperis longi stomach-ache granules | 扬子江药业集团江苏龙凤堂中药有限公司 | 2021-01-15 | — | — | CN | claimed |
| CN-110179800-B | Acetylcholinesterase inhibitor, Alzheimer disease preventive and therapeutic agent, and production method thereof | 香港科技大学深圳研究院 | 2021-01-05 | — | — | CN | claimed |
| CN-108562656-B | Method for measuring content of alkaloid and paeonol in traditional Chinese medicine preparation | 广西壮族自治区食品药品检验所 | 2020-11-17 | — | — | CN | claimed |
| CN-111480654-A | Application of coptisine substances as herbicide | 华南农业大学 | 2020-08-04 | — | — | CN | claimed |
| CN-110849988-A | Method for detecting 33 alkaloids in honey | 徐敦明 | 2020-02-28 | — | — | CN | claimed |
| CN-107445952-B | Method for extracting gladiolide and coptisine and application | 贵州师范学院 | 2019-12-24 | — | — | CN | claimed |
| CN-107445952-A | A kind of with extracting Glan new and coptisine methods and applications | 贵州师范学院 | 2017-12-08 | — | — | CN | claimed |
| CN-103059016-A | Coptisine derivatives as well as synthesis methods and medicinal application thereof to resistance of tumors | INST MATERIA MEDICA CAMS | 2013-04-24 | — | — | CN | claimed |